NBCE Exam 2025 – 400 Free Practice Questions to Pass the National Board of Chiropractic Examiners

The term that describes the abnormal growth of osteoclasts leading to increased bone resorption and disorganized bone development is Paget's disease. In Paget's disease, there is a dysregulation of the normal remodeling process of bone, primarily characterized by an increase in the number and activity of osteoclasts. This results in excessive bone breakdown (resorption) followed by chaotic attempts at new bone formation, leading to structurally disorganized and weakened bone.

The clinical presentation of Paget's disease can include pain, deformities, and an increased risk of fractures due to the compromised structural integrity of the bone. Imaging studies typically reveal enlarged and structurally irregular bones, and it's often diagnosed in middle-aged or older adults.

Understanding the specifics of how Paget's disease affects bone tissue can help in recognizing its potential complications and managing treatment effectively.