NBCE Exam 2025 – 400 Free Practice Questions to Pass the National Board of Chiropractic Examiners

Cushing's Syndrome is characterized by an excess of cortisol in the body, which can occur due to various reasons, including adrenal tumors, pituitary adenomas, or prolonged use of corticosteroid medications. One of the well-documented complications associated with this condition is osteoporosis.

The elevated levels of cortisol lead to a reduction in bone density by inhibiting osteoblast function (the cells responsible for bone formation) and promoting osteoclast activity (the cells responsible for bone resorption). This imbalance contributes to increased bone fragility and a higher risk of fractures.

Patients with Cushing's Syndrome often experience not only a decrease in bone mass but may also suffer from other factors associated with cortisol excess, such as muscle weakness and changes in metabolism, which can compound the risks associated with osteoporosis. Thus, recognizing osteoporosis as a common complication of Cushing's Syndrome is crucial for proper management and prevention of further health issues in affected individuals.